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Paromomycin Sulfate

CAT: 0013-GTR19176803-03Size: 25 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19176803-03Size:25 g
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Description
Paromomycin sulfate is an aminoglycoside antibiotic that binds to the 16S rRNA in the bacterial 30S ribosomal A-site, inducing translational misreading and inhibition of protein synthesis. It is widely used in research involving gram-negative bacterial infections, including in vitro antimicrobial studies and in vivo models of amebiasis.
CAS Number
1263-89-4
Product Name Alternative
Tapeworm infection, Parasite, parasitic, Paromomycin, Paromomycin Sulfate, Paromomycin sulfate salt, leishmaniasis, giardiasis, Aminosidine, Aminosidine sulfate, amebiasis, Antibiotic, Bacterial, 16S rRNA
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
≥98% (May vary between batches)
Solubility
H2O:255 mg/mL (357.29 mM) ; DMSO:Insoluble
Smiles
OS (O) (=O) =O.NC[C@@H]1O[C@H] (O[C@@H]2[C@@H] (CO) O[C@@H] (O[C@@H]3[C@@H] (O) [C@H] (N) C[C@H] (N) [C@H]3O[C@H]3O[C@H] (CO) [C@@H] (O) [C@H] (O) [C@H]3N) [C@@H]2O) [C@H] (N) [C@@H] (O) [C@@H]1O
Molecular Formula
C23H47N5O18S
Molecular Weight
713.71
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Paromomycin Sulfate

Paromomycin sulfate is an aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. It has a role as an antiparasitic agent, an anthelminthic drug, an antiprotozoal drug and an antibacterial drug. It is functionally related to a paromomycin.

CAS Number1263-89-4
PubChem CID441375
IUPAC Name(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
Molecular FormulaC23H47N5O18S
Molecular Weight713.7
Topological Polar Surface Area430
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count23
Rotatable Bond Count9
Heavy Atom Count47
Formal Charge0
Complexity952
SMILES
C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
InChI
InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChIKey
LJRDOKAZOAKLDU-UDXJMMFXSA-N
Chemical Structure
2D Structure
2D structure of Paromomycin Sulfate
CAS: 1263-89-4
CID: 441375
Formula: C23H47N5O18S
MW: 713.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight713.7
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count23
Rotatable Bond Count9
Exact Mass713.26368084
Monoisotopic Mass713.26368084
Topological Polar Surface Area430 Ų
Heavy Atom Count47
Formal Charge0
Complexity952
Isotope Atom Count0
Defined Atom Stereocenter Count19
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1808-50Paromomycin Sulfate
HY-B0956-01Paromomycin (sulfate)

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