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DMAPT

CAT: 0013-GTR19176796-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176796-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMAPT is an orally bioavailable dimethylamino analog of parthenolide that potently inhibits NF-κB. It demonstrates cytotoxic activity against primary AML cells with an LD50 of 1.7 μM and has been investigated in preclinical studies for its potential anti-tumor and anti-metastatic properties in both cellular and animal models.
CAS Number
870677-05-7
Product Name Alternative
Dimethylamino Parthenolide, DMAPT, inhibit, NF-κB, Nuclear factor-kappaB, Nuclear factor-κB, NF-kB, NFkB, NFκB, Inhibitor
Field of Research
Cell Biology
Purity
>99%
Bioactivity
NFkB inhibitor
Form
Powder
Solubility
Soluble in DMSO, Ethyl acetate, or Ethanol.
Smiles
[H][C@@]12CC\C (C) =C/CC[C@@]3 (C) O[C@@H]3[C@@]1 ([H]) OC (=O) [C@@H]2CN (C) C
Molecular Formula
C17H27NO3
Molecular Weight
293.41
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Dimethylamino-parthenolide

Chemical Information

Dimethylaminoparthenolide
CAS Number870677-05-7
PubChem CID129395999
IUPAC Name(1S,2R,4R,7Z,11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
Molecular FormulaC17H27NO3
Molecular Weight293.4
XLogP1.9
Topological Polar Surface Area42.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity459
SMILES
C/C/1=C/CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)[C@H](C(=O)O3)CN(C)C)C
InChI
InChI=1S/C17H27NO3/c1-11-6-5-9-17(2)15(21-17)14-12(8-7-11)13(10-18(3)4)16(19)20-14/h6,12-15H,5,7-10H2,1-4H3/b11-6-/t12-,13+,14-,15+,17+/m0/s1
InChIKey
UJNSFDHVIBGEJZ-CMRIBGNTSA-N
Chemical Structure
2D Structure
2D structure of Dimethylaminoparthenolide
CAS: 870677-05-7
CID: 129395999
Formula: C17H27NO3
MW: 293.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.4
XLogP31.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass293.19909372
Monoisotopic Mass293.19909372
Topological Polar Surface Area42.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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