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Chloramphenicol

CAT: 0013-GTR19176649-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176649-01Size:500 mg
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Description
Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit and blocking peptidyl transferase activity. It is widely used in molecular biology and microbiological research, both in vitro and in animal infection models, to study protein synthesis and antibiotic mechanisms.
CAS Number
56-75-7
Product Name Alternative
Chloramphenicol, Chlornitromycin, Chloromycetin, 50S ribosome, A549, Akt, Aplastic anaemia, Antibiotic, anaerobic infections, Autophagy, Atg6, Apoptosis, Bacterial, Beclin1, H1299, Hypoxia-inducible factors, HIFs, HIFProlylHydroxylase, HIF-PH, HIF, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, Matrix metalloproteinases, Levomycetin, mitochondria stress, MMP, Inhibitor, JNK, inhibit, PKB, PI-3K, SENP-1, Protein kinase B, Vascular endothelial growth factor receptor, VEGFR
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction
Purity
99.60% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.47 mM) ; Ethanol:60 mg/mL (185.68 mM) ; H2O:1 mg/mL (3.09 mM) ; DMSO:250 mg/mL (773.68 mM)
Smiles
[C@@H] ([C@H] (NC (C (Cl) Cl) =O) CO) (O) C1=CC=C (N (=O) =O) C=C1
Molecular Formula
C11H12Cl2N2O5
Molecular Weight
323.13
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Chloramphenicol

Chloramphenicol is an organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions. It has a role as a Mycoplasma genitalium metabolite, a geroprotector, an antimicrobial agent, an antibacterial drug, a protein synthesis inhibitor and an Escherichia coli metabolite. It is a diol, a C-nitro compound, an organochlorine compound and a carboxamide.

CAS Number56-75-7
PubChem CID5959
IUPAC Name2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Molecular FormulaC11H12Cl2N2O5
Molecular Weight323.13
XLogP1.1
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count20
Formal Charge0
Complexity342
SMILES
C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
InChI
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChIKey
WIIZWVCIJKGZOK-RKDXNWHRSA-N
Chemical Structure
2D Structure
2D structure of Chloramphenicol
CAS: 56-75-7
CID: 5959
Formula: C11H12Cl2N2O5
MW: 323.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.13
XLogP31.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass322.0123269
Monoisotopic Mass322.0123269
Topological Polar Surface Area115 Ų
Heavy Atom Count20
Formal Charge0
Complexity342
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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