Betahistine dihydrochloride

CAT: 0013-GTR19176313-01Size: 1 gDry Ice: NoHazardous: No

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Description

Betahistine dihydrochloride is a histamine H1 receptor agonist and vasodilatory agent. It is widely used in research models for studying vestibular function, Meniere's disease, and vascular responses in both in vitro and in vivo experimental systems.

CAS Number

5579-84-0

Product Name Alternative

PT 9, PT9, PT-9, Rheumatoid, schizophrenia, inhibit, H3 receptor, episode, Ménière, Inhibitor, Histamine Receptor, HistamineReceptor, arthritis, antipsychotic, disease, Betahistine, Betahistine 2HCl, Betahistine Dihydrochloride, Betahistine dihydrochloride, CIA

Field of Research

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Purity

99.22% (May vary between batches)

Solubility

Ethanol:1 mg/mL (4.78 mM) ; H2O:35 mg/mL (167.37 mM) ; DMSO:50 mg/mL (239.1 mM)

Smiles

Cl.Cl.CNCCC1=NC=CC=C1

Molecular Formula

C8H14Cl2N2

Molecular Weight

209.12

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Betahistine Hydrochloride

Betahistine Hydrochloride is the hydrochloride salt form of betahistine, a histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties. Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors and exerts its agonistic and antagonistic actions locally and centrally. This promotes cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular nuclei and increases histamine synthesis and release in the brain which facilitates vestibular compensation. Increased blood flow around the inner ear reduces the amount of fluid in the inner ear and may alleviate vertigo, tinnitus, and hearing loss.

CAS Number	5579-84-0
PubChem CID	68643
IUPAC Name	N-methyl-2-pyridin-2-ylethanamine;dihydrochloride
Molecular Formula	C8H14Cl2N2
Molecular Weight	209.11
Topological Polar Surface Area	24.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	12
Formal Charge	0
Complexity	83

SMILES

CNCCC1=CC=CC=N1.Cl.Cl

InChI

InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H

InChIKey

XVDFMHARQUBJRE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 5579-84-0

CID: 68643

Formula: C8H14Cl2N2

MW: 209.11

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	209.11
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	208.0534038
Monoisotopic Mass	208.0534038
Topological Polar Surface Area	24.9 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	83.3
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	3
Compound Is Canonicalized	Yes

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Catalog	Name
FB138972-01	Betahistine dihydrochloride
HY-B0524A-01	Betahistine (dihydrochloride)
TRC-B324002-50MG	Betahistine-d3 Dihydrochloride
HY-B0524AR-01	Betahistine (dihydrochloride) (Standard)
HY-B0524AS-01	Betahistine-d3 (dihydrochloride)
TRC-B324030-250MG	Betahistine N-Oxide Dihydrochloride
CS-SN-00007	Betahistine-13C, D3 Dihydrochloride
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Betahistine dihydrochloride

Chemical Information

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