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Clomipramine hydrochloride

CAT: 0013-GTR19176303-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19176303-01Size:1 ml x 10 mM (in DMSO)
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Description
Clomipramine hydrochloride is a tricyclic antidepressant that acts as a selective serotonin reuptake inhibitor. Following oral absorption and hepatic conversion to desmethylclomipramine, it is used in research models of depression, OCD, and neuropathic pain for in vivo and in vitro pharmacological studies.
CAS Number
17321-77-6
Product Name Alternative
DAT, depression, Dopamine Receptor, DopamineReceptor, Clomipramine hydrochloride, Clomipramine Hydrochloride, Clomipramine HCl, Clomipramine, Chlorimipramine, Antidepressant, Anafranil, 5-HT, 5HT Receptor, 5-HTT, 5HTReceptor, 5-hydroxytryptamine, 5-HT reuptake, G34586, G-34586, G 34586, GSTP, Inhibitor, hyperglycemia, NSC 169865, Noradrenaline transporter (Sodium-dependent), inhibit, NSC169865, NSC-169865, obsessive compulsive disorder, OCD, Sert (Sodium-dependent), SERT, Serotonin Transporter, SerotoninTransporter, SLC6A4
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Purity
99.04% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.85 mM) ; H2O:142.32 mM; DMSO:7.5 mg/mL (21.35 mM)
Smiles
Cl.CN (C) CCCN1c2ccccc2CCc2c1cc (Cl) cc2
Molecular Formula
C19H23ClN2·HCl
Molecular Weight
351.31
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Clomipramine Hydrochloride

Clomipramine hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias. It has a role as an anticoronaviral agent, an antidepressant, a serotonergic drug and a serotonergic antagonist. It contains a clomipramine(1+).

CAS Number17321-77-6
PubChem CID68539
IUPAC Name3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Molecular FormulaC19H24Cl2N2
Molecular Weight351.3
Topological Polar Surface Area6.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity346
SMILES
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
InChI
InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
InChIKey
WIMWMKZEIBHDTH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Clomipramine Hydrochloride
CAS: 17321-77-6
CID: 68539
Formula: C19H24Cl2N2
MW: 351.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight351.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass350.1316542
Monoisotopic Mass350.1316542
Topological Polar Surface Area6.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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