Clomipramine-d6 (hydrochloride)

Clomipramine-d6 (hydrochloride)

• CAS Number: 1189882-28-7
• UNSPSC Description: Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
• Target Antigen: Isotope-Labeled Compounds; Serotonin Transporter
• Type: Isotope-Labeled Compounds
• Related Pathways: Neuronal Signaling;Others
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])N(C([2H])([2H])[2H])CCCN1C2=CC(Cl)=CC=C2CCC3=CC=CC=C31.Cl[H]
• Molecular Weight: 357.35
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9.|[3]Mushtaq Ahmed, et al. Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum. J Enzyme Inhib Med Chem. 2008 Dec;23(6):912-7.|[4]Federica Cavaliere,The tricyclic antidepressant Clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported