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(±) -10-Hydroxycamptothecin

CAT: 0013-GTR19175337-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175337-07Size:500 mg
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Description
(±) -10-Hydroxycamptothecin is a natural alkaloid derived from Camptotheca acuminata that acts as a selective inhibitor of DNA topoisomerase I. It serves as a key research compound for studying anticancer mechanisms and has been used in both in vitro cytotoxicity assays and in vivo tumor model studies to evaluate its therapeutic potential.
CAS Number
64439-81-2
Product Name Alternative
Topoisomerase, Topo I, Inhibitor, Hydroxy Camptothecine, inhibit, (±) 10 Hydroxycamptothecin, (±) 10Hydroxycamptothecin, 10-Hydroxycamptothecin
Field of Research
Molecular Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:29.71 mg/mL (81.54 mM)
Smiles
CCC1 (O) C (=O) OCc2c1cc1-c3nc4ccc (O) cc4cc3Cn1c2=O
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-Ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione

See also: Hydroxycamptothecin (annotation moved to) ... View More ...

CAS Number64439-81-2
PubChem CID4330531
IUPAC Name19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
Molecular FormulaC20H16N2O5
Molecular Weight364.4
XLogP0.6
Topological Polar Surface Area100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count27
Formal Charge0
Complexity774
SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChIKey
HAWSQZCWOQZXHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
CAS: 64439-81-2
CID: 4330531
Formula: C20H16N2O5
MW: 364.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.4
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass364.10592162
Monoisotopic Mass364.10592162
Topological Polar Surface Area100 Ų
Heavy Atom Count27
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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