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ESI-05

CAT: 0013-GTR19175316-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175316-01Size:2 mg
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Description
ESI-05 (NSC-116966) is a selective EPAC2 antagonist with an IC50 of 0.4 μM, effectively blocking cAMP-induced EPAC2 activation and subsequent Rap1 signaling. This tool compound is utilized in vitro and in vivo to investigate EPAC2's role in insulin secretion, neuronal function, and potential therapeutic applications for diabetes and neurological disorders.
CAS Number
5184-64-5
Product Name Alternative
Diglyceride acyltransferase, Diacylglycerol acyltransferase, diabetes, acyl-CoA:cholesterol acyltransferase, Acyltransferase, cAMP, inhibit, Intracranial hemorrhage (ICH), NSC 116966, NSC116966, NSC-116966, Inhibitor, neurological disorders, insulin secretion, GEF, mono- acylglycerol acyltransferase, ESI 05, ESI05, ESI-05, EPAC2, exchange proteins directly activated by cAMP 2 (EPAC2)
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
97.22% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (12.03 mM) ; DMSO:83.33 mg/mL (303.7 mM)
Smiles
Cc1ccc (cc1) S (=O) (=O) c1c (C) cc (C) cc1C
Molecular Formula
C16H18O2S
Molecular Weight
274.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1,3,5-Trimethyl-2-tosylbenzene
CAS Number5184-64-5
PubChem CID272513
IUPAC Name1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
Molecular FormulaC16H18O2S
Molecular Weight274.4
XLogP4.1
Topological Polar Surface Area42.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity375
SMILES
CC1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2C)C)C
InChI
InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
InChIKey
CGPHOZWFSFNOEQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,3,5-Trimethyl-2-tosylbenzene
CAS: 5184-64-5
CID: 272513
Formula: C16H18O2S
MW: 274.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight274.4
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass274.10275099
Monoisotopic Mass274.10275099
Topological Polar Surface Area42.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BLG-M092-25ESI-05
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A18644-25ESI-05 25mg
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A18644-100ESI-05 100mg
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