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Ciclopirox

CAT: 0013-GTR19175086-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175086-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ciclopirox is a broad-spectrum synthetic antifungal agent that acts by chelating trivalent metal ions like Fe3+, disrupting essential fungal enzymes and cell wall integrity. Its additional anti-inflammatory properties arise from inhibiting 5-lipoxygenase and cyclooxygenase. This mechanism supports its research use in studying dermatophyte infections and inflammatory pathways in both in vitro and in vivo models.
CAS Number
29342-05-0
Product Name Alternative
Ciclopirox, Autophagy, Bacterial, Fungal, Ferroptosis, Inhibitor, HOE296b, Na+/K+-ATPase, inhibit
Field of Research
Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
97.72% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.65 mM) ; DMSO:101 mg/mL (487.29 mM) ; Ethanol:20.7 mg/mL (99.87 mM)
Smiles
ON1C (=CC (C) =CC1=O) C2CCCCC2
Molecular Formula
C12H17NO2
Molecular Weight
207.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ciclopirox

Ciclopirox is a cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections. It has a role as an antibacterial agent and an antiseborrheic. It is a cyclic hydroxamic acid, a pyridone and a hydroxypyridone antifungal drug.

CAS Number29342-05-0
PubChem CID2749
IUPAC Name6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
Molecular FormulaC12H17NO2
Molecular Weight207.27
XLogP2
Topological Polar Surface Area40.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity325
SMILES
CC1=CC(=O)N(C(=C1)C2CCCCC2)O
InChI
InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
InChIKey
SCKYRAXSEDYPSA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ciclopirox
CAS: 29342-05-0
CID: 2749
Formula: C12H17NO2
MW: 207.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight207.27
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass207.125928785
Monoisotopic Mass207.125928785
Topological Polar Surface Area40.5 Ų
Heavy Atom Count15
Formal Charge0
Complexity325
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-B0450-01Ciclopirox

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