Ciclopirox

CAT: 0804-HY-B0450-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0450-01Size:50 mg
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Description
Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect[1][2][3].
CAS Number
[29342-05-0]
Product Name Alternative
HOE296b
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Bacterial; Ferroptosis; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Ciclopirox.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C(C1CCCCC1)N2O)=CC2=O
Molecular Formula
C12H17NO2
Molecular Weight
207.27
Precautions
H302
References & Citations
[1]Niewerth, M., et al., Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother, 2003. 47 (6) : p. 1805-17.|[2]Leem, S.H., et al., The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Mol Cells, 2003. 15 (1) : p. 55-61.|[3]Ratnavel, R.C., R.A. Squire, and G.C. Boorman, Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis. J Dermatolog Treat, 2007. 18 (2) : p. 88-96.|[4]Clement PM, et al. The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro. Int J Cancer. 2002 Aug 1;100 (4) :491-8. |[5]Lu J, et al. Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells. Cell Commun Signal. 2022 Mar 24;20 (1) :37.|[6]Zhou H, et al. The antitumor activity of the fungicide ciclopirox. Int J Cancer. 2010 Nov 15;127 (10) :2467-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Death Dis. 2025 May 19;16 (1) :403.|Clin Transl Med. 2022 Aug;12 (8) :e999.|Eur J Pharmacol. 2022 Sep 5:930:175156.|Front Pharmacol. 2021 May 10:12:670224.|J Agric Food Chem. 2025 Aug 13;73 (32) :20385-20395.|Mol Cell Biochem. 2024 May 24.|Mol Neurobiol. 2025 Apr;62 (4) :4055-4075.|Adv Healthc Mater. 2025 Jan 24:e2405085.|Pharmacol Res. 2022 Feb:176:106046.

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