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Heclin

CAT: 0013-GTR19174910-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174910-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Heclin is a cell-permeable small molecule inhibitor targeting the HECT domain of E3 ubiquitin ligases, including Smurf2, Nedd4, and WWP1, with IC50 values ranging from 6.3 to 6.9 μM. It is a valuable research tool for studying ubiquitination pathways in cellular and biochemical assays, applicable in cancer and developmental biology research.
CAS Number
890605-54-6
Product Name Alternative
E1Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1 activating enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3 ligating enzyme, E3Enzyme, inhibit, HECT E3 ubiquitin ligase, Heclin, Inhibitor, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme
Field of Research
Cell Biology, Protein Biochemistry
Purity
>98%
Bioactivity
HECT domain containing E3 ubiquitin ligase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml) .
Smiles
CCc1ccc (\C=C\C (=O) Nc2ccc (cc2) C (C) =O) o1
Molecular Formula
C17H17NO3
Molecular Weight
283.33
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2E-N- (4-Acetylphenyl) -3- (5-ethylfuran-2-yl) prop-2-enamide

Chemical Information

(2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide
CAS Number890605-54-6
PubChem CID7464118
IUPAC Name(E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide
Molecular FormulaC17H17NO3
Molecular Weight283.32
XLogP2.8
Topological Polar Surface Area59.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count21
Formal Charge0
Complexity397
SMILES
CCC1=CC=C(O1)/C=C/C(=O)NC2=CC=C(C=C2)C(=O)C
InChI
InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+
InChIKey
SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Chemical Structure
2D Structure
2D structure of (2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide
CAS: 890605-54-6
CID: 7464118
Formula: C17H17NO3
MW: 283.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight283.32
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass283.12084340
Monoisotopic Mass283.12084340
Topological Polar Surface Area59.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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