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(E/Z) -BIX 02189

CAT: 0013-GTR19174905-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174905-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -BIX 02189 is a stereoisomer of the MEK5 inhibitor BIX 02189. This chemical probe is utilized in biochemical studies to investigate the ERK5 signaling pathway in both cellular and enzymatic assays.
CAS Number
1094614-85-3
Product Name Alternative
BIX 02189, BIX02189, BIX-02189, MEK1, MEK2, MEK5, ERK5, TGFbeta/Smad, TGF-beta, TGFb, TGF-b/Smad, TGFbeta, Smad, TGFβR1, TGFβ, TGF-β/Smad
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:74 mg/mL (167.98 mM) ; DMSO:22.73 mg/mL (51.6 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM)
Smiles
C (NC1=CC (CN (C) C) =CC=C1) (=C2C=3C (NC2=O) =CC (C (N (C) C) =O) =CC3) C4=CC=CC=C4
Molecular Formula
C27H28N4O2
Molecular Weight
440.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

CAS Number1094614-85-3
PubChem CID135659062
IUPAC Name3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-N,N-dimethyl-1H-indole-6-carboxamide
Molecular FormulaC27H28N4O2
Molecular Weight440.5
XLogP4.5
Topological Polar Surface Area71.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity688
SMILES
CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O
InChI
InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,29,32H,17H2,1-4H3
InChIKey
ZGXOBLVQIVXKEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
CAS: 1094614-85-3
CID: 135659062
Formula: C27H28N4O2
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass440.22122615
Monoisotopic Mass440.22122615
Topological Polar Surface Area71.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T2416-01(E/Z) -BIX 02189
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