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IC261

CAT: 0013-GTR19174871-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174871-01Size:5 mg
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Description
IC261 (SU-5607) is a selective casein kinase 1 (CK1) inhibitor with an IC50 of 16 μM, which is significantly more potent than its activity against Cdk5 (IC50 4.5 mM) . It activates the mitotic checkpoint and is widely used in vitro to study cell cycle regulation, apoptosis, and circadian rhythms.
CAS Number
186611-52-9
Product Name Alternative
CDK5, CK1, Casein Kinase, CaseinKinase, Apoptosis, inhibit, Inhibitor, IC-261, IC261, IC 261, SU 5607, SU5607, SU-5607
Field of Research
Cell Biology, Metabolism Research, Stem Cell & Developmental Biology
Purity
98.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.42 mM) ; DMSO:70 mg/mL (224.84 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
COc1cc (OC) c (\C=C2\C (=O) Nc3ccccc23) c (OC) c1
Molecular Formula
C18H17NO4
Molecular Weight
311.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

IC261

a caseine kinase-1 inhibitor; structure in first source

CAS Number186611-52-9
PubChem CID5288600
IUPAC Name(3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one
Molecular FormulaC18H17NO4
Molecular Weight311.3
XLogP2.8
Topological Polar Surface Area56.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity450
SMILES
COC1=CC(=C(C(=C1)OC)/C=C/2\C3=CC=CC=C3NC2=O)OC
InChI
InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+
InChIKey
JBJYTZXCZDNOJW-JLHYYAGUSA-N
Chemical Structure
2D Structure
2D structure of IC261
CAS: 186611-52-9
CID: 5288600
Formula: C18H17NO4
MW: 311.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight311.3
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass311.11575802
Monoisotopic Mass311.11575802
Topological Polar Surface Area56.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C18142-100mgIC261

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