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PIK-75

CAT: 0013-GTR19174774-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174774-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PIK-75 is a potent dual inhibitor of DNA-PK and PI3K, exhibiting low nanomolar IC50 values against DNA-PK (2 nM) and p110α (5.8 nM), with additional activity against p110γ (76 nM) . This small molecule is a valuable research tool for investigating DNA damage response and PI3K signaling pathways in both cellular and biochemical assays.
CAS Number
372196-67-3
Product Name Alternative
DNA-dependent protein kinase, DNAPK, DNA-PK, cells, CHO-IR, apoptotic, Apoptosis, cancer, pancreatic, inhibit, Inhibitor, PKB, PI3K, Phosphoinositide 3-kinase, PIK 75, PIK75, PIK-75, p110α, p110β, p110γ, p110δ
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
98.19% (May vary between batches)
Solubility
DMSO:4.53 mg/mL (10.02 mM)
Smiles
CN (\N=C\c1cnc2ccc (Br) cn12) S (=O) (=O) c1cc (ccc1C) [N+] ([O-]) =O
Molecular Formula
C16H14BrN5O4S
Molecular Weight
452.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pik-75

N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.

CAS Number372196-67-3
PubChem CID10275789
IUPAC NameN-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide
Molecular FormulaC16H14BrN5O4S
Molecular Weight452.3
XLogP3.8
Topological Polar Surface Area121
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity679
SMILES
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br
InChI
InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
InChIKey
QTHCAAFKVUWAFI-DJKKODMXSA-N
Chemical Structure
2D Structure
2D structure of Pik-75
CAS: 372196-67-3
CID: 10275789
Formula: C16H14BrN5O4S
MW: 452.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight452.3
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass450.99499
Monoisotopic Mass450.99499
Topological Polar Surface Area121 Ų
Heavy Atom Count27
Formal Charge0
Complexity679
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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