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PIK-293

CAT: 0013-GTR19172913-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172913-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PIK-293 is a selective small molecule inhibitor of phosphoinositide 3-kinase delta (PI3Kδ) with an IC50 of 0.24 μM, demonstrating lower activity against the PI3Kα, β, and γ isoforms. This compound is a valuable research tool for studying PI3Kδ signaling in immunological and oncological contexts, applicable in both in vitro and in vivo experimental models.
CAS Number
900185-01-5
Product Name Alternative
PIK293, PIK-293, PIK 293, PI3K, Phosphoinositide 3-kinase, Inhibitor, inhibit, p110δ, p110γ, p110β, p110α
Field of Research
Signal Transduction
Purity
99.65% (May vary between batches)
Solubility
DMSO:80 mg/mL (201.29 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.03 mM)
Smiles
Cc1ccccc1-n1c (Cn2ncc3c (N) ncnc23) nc2cccc (C) c2c1=O
Molecular Formula
C22H19N7O
Molecular Weight
397.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
CAS Number900185-01-5
PubChem CID53245636
IUPAC Name2-[(4-aminopyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one
Molecular FormulaC22H19N7O
Molecular Weight397.4
XLogP2.9
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity684
SMILES
CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C=N4)N
InChI
InChI=1S/C22H19N7O/c1-13-6-3-4-9-17(13)29-18(27-16-8-5-7-14(2)19(16)22(29)30)11-28-21-15(10-26-28)20(23)24-12-25-21/h3-10,12H,11H2,1-2H3,(H2,23,24,25)
InChIKey
KQDBVHKNIYROHU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
CAS: 900185-01-5
CID: 53245636
Formula: C22H19N7O
MW: 397.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.4
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass397.16510826
Monoisotopic Mass397.16510826
Topological Polar Surface Area102 Ų
Heavy Atom Count30
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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