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Hydrocortisone

CAT: 0013-GTR19174548-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174548-01Size:200 mg
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Description
Hydrocortisone (Cortisol) is an endogenous glucocorticoid that activates the glucocorticoid receptor, modulating metabolism, immune function, and inflammation. It is widely used in research to study stress responses, inflammatory pathways, and immune regulation in both cellular and animal models.
CAS Number
50-23-7
Product Name Alternative
Cortisol, Endogenous Metabolite, Hydrocortisone, Glucocorticoid Receptor, GlucocorticoidReceptor, EndogenousMetabolite, Inhibitor, inhibit
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
98.40% (May vary between batches)
Solubility
DMSO: 127.5 mg/mL (351.76 mM), Sonication is recommended. Ethanol: 22 mg/mL (60.7 mM), Sonication is recommended.
Smiles
C[C@@]12[C@] ([C@]3 ([C@@] ([C@]4 (C) C (CC3) =CC (=O) CC4) ([C@@H] (O) C1) [H]) [H]) (CC[C@@]2 (C (CO) =O) O) [H]
Molecular Formula
C21H30O5
Molecular Weight
362.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cortisol

Cortisol is a 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses. It has a role as an anti-inflammatory drug, an anti-asthmatic drug, an anti-allergic agent, a mouse metabolite, a human metabolite and a drug allergen. It is a 17alpha-hydroxy-C21-steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid and a 3-oxo-Delta(4) steroid. It derives from a hydride of a pregnane.

CAS Number50-23-7
PubChem CID5754
IUPAC Name(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular FormulaC21H30O5
Molecular Weight362.5
XLogP1.6
Topological Polar Surface Area94.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity684
SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey
JYGXADMDTFJGBT-VWUMJDOOSA-N
Chemical Structure
2D Structure
2D structure of Cortisol
CAS: 50-23-7
CID: 5754
Formula: C21H30O5
MW: 362.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.5
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass362.20932405
Monoisotopic Mass362.20932405
Topological Polar Surface Area94.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FH16250-01Hydrocortisone

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