PF-3644022

CAT: 0013-GTR19174531-05Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19174531-05Size:25 mg

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Description

PF-3644022 is a potent and selective ATP-competitive inhibitor of MAPKAPK2 (MK2) with an IC50 of 5.2 nM. It also inhibits MK3 and PRAK and suppresses TNFα production, demonstrating anti-inflammatory effects in cellular assays. This compound is a valuable research tool for studying p38 MAPK signaling in inflammation and related disease models.

CAS Number

1276121-88-0

Product Name Alternative

Anti-inflammatory, MAP kinase activated protein kinase 2, MAPK activated protein kinase 2, MAPKAP kinase 2, MAPKAPK2 (MK2), Inhibitor, efficacious, Mitogen-activated protein kinase activated protein kinase 2, MK2, MK3, orally, lipopolysaccharide, inhibit, IL-6, monocytic, TNFα, Serine Protease, SerineProtease, PF 3644022, PRAK, PF3644022, PF-3644022, p38MAPK, p38 MAPK, safety

Field of Research

Protein Biochemistry, Signal Transduction

Purity

98.13% (May vary between batches)

Solubility

DMSO:41.67 mg/mL (111.28 mM)

Smiles

C[C@@H]1CNc2c (sc3ccc4nc (ccc4c23) -c2ccc (C) nc2) C (=O) N1

Molecular Formula

C21H18N4OS

Molecular Weight

374.46

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

PF-3644022

CAS Number	1276121-88-0
PubChem CID	44631903
IUPAC Name	(15R)-15-methyl-5-(6-methyl-3-pyridinyl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one
Molecular Formula	C21H18N4OS
Molecular Weight	374.5
XLogP	4
Topological Polar Surface Area	95.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	27
Formal Charge	0
Complexity	574

SMILES

C[C@@H]1CNC2=C(C(=O)N1)SC3=C2C4=C(C=C3)N=C(C=C4)C5=CN=C(C=C5)C

InChI

InChI=1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1

InChIKey

CMWRPDHVGMHLSZ-GFCCVEGCSA-N

Chemical Structure

2D Structure

CAS: 1276121-88-0

CID: 44631903

Formula: C21H18N4OS

MW: 374.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	374.5
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	374.12013238
Monoisotopic Mass	374.12013238
Topological Polar Surface Area	95.2 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	574
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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B5549-10	PF-3644022
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A11282-500	PF-3644022 500mg
A11282-5	PF-3644022 5mg
A11282-100	PF-3644022 100mg

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