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PF-3644022

CAT: 0013-GTR19174531-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174531-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-3644022 is a potent and selective ATP-competitive inhibitor of MAPKAPK2 (MK2) with an IC50 of 5.2 nM. It also inhibits MK3 and PRAK and suppresses TNFα production, demonstrating anti-inflammatory effects in cellular assays. This compound is a valuable research tool for studying p38 MAPK signaling in inflammation and related disease models.
CAS Number
1276121-88-0
Product Name Alternative
Anti-inflammatory, MAP kinase activated protein kinase 2, MAPK activated protein kinase 2, MAPKAP kinase 2, MAPKAPK2 (MK2), Inhibitor, efficacious, Mitogen-activated protein kinase activated protein kinase 2, MK2, MK3, orally, lipopolysaccharide, inhibit, IL-6, monocytic, TNFα, Serine Protease, SerineProtease, PF 3644022, PRAK, PF3644022, PF-3644022, p38MAPK, p38 MAPK, safety
Field of Research
Protein Biochemistry, Signal Transduction
Purity
98.13% (May vary between batches)
Solubility
DMSO:41.67 mg/mL (111.28 mM)
Smiles
C[C@@H]1CNc2c (sc3ccc4nc (ccc4c23) -c2ccc (C) nc2) C (=O) N1
Molecular Formula
C21H18N4OS
Molecular Weight
374.46
Storage Conditions
-20°C
Notes
For research use only.

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B5549-10PF-3644022
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