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GW-870086

CAT: 0013-GTR19174469-08Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174469-08Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW-870086 is a potent glucocorticoid receptor agonist with anti-inflammatory activity, demonstrating a pIC50 of 10.1 in NF-κB reporter assays using A549 cells. It is a valuable research tool for studying glucocorticoid receptor signaling and inflammation in both cellular and animal models.
CAS Number
827319-43-7
Product Name Alternative
Inhibitor, GW870086, GW-870086, GW 870086, GlucocorticoidReceptor, Glucocorticoid Receptor, glucocorticoid receptor, glucocorticoid receptor, A549 NF-κB cells, inhibit
Field of Research
Metabolism Research
Purity
99.63% (May vary between batches)
Solubility
DMSO:11 mg/mL (19.66 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.57 mM)
Smiles
[H][C@@]12C[C@@H] (C) [C@] (OC (=O) C3C (C) (C) C3 (C) C) (C (=O) OCC#N) [C@@]1 (C) C[C@H] (O) [C@@]1 (F) [C@@]2 ([H]) C[C@H] (F) C2=CC (=O) C=C[C@]12C
Molecular Formula
C31H39F2NO6
Molecular Weight
559.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gw-870086

GW870086X has been investigated for the treatment of ASTHMA.

CAS Number827319-43-7
PubChem CID11376392
IUPAC Namecyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate
Molecular FormulaC31H39F2NO6
Molecular Weight559.6
XLogP4.7
Topological Polar Surface Area114
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count40
Formal Charge0
Complexity1280
SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)OCC#N)OC(=O)C5C(C5(C)C)(C)C)C)O)F)C)F
InChI
InChI=1S/C31H39F2NO6/c1-16-12-18-19-14-21(32)20-13-17(35)8-9-28(20,6)30(19,33)22(36)15-29(18,7)31(16,25(38)39-11-10-34)40-24(37)23-26(2,3)27(23,4)5/h8-9,13,16,18-19,21-23,36H,11-12,14-15H2,1-7H3/t16-,18+,19+,21+,22+,28+,29+,30+,31+/m1/s1
InChIKey
WUBKGTSFJSEIEM-NSHBDUGJSA-N
Chemical Structure
2D Structure
2D structure of Gw-870086
CAS: 827319-43-7
CID: 11376392
Formula: C31H39F2NO6
MW: 559.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight559.6
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass559.27454429
Monoisotopic Mass559.27454429
Topological Polar Surface Area114 Ų
Heavy Atom Count40
Formal Charge0
Complexity1280
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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