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JH-RE-06

CAT: 0013-GTR19174406-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174406-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JH-RE-06 is a small molecule inhibitor of the REV1-REV7 interaction, effectively blocking mutagenic POLζ recruitment during translesion synthesis (IC50=0.78 μM) . It serves as a chemical probe for studying DNA damage tolerance and has shown potential to enhance chemotherapy efficacy in preclinical cancer models.
CAS Number
1361227-90-8
Product Name Alternative
RNA Synthesis, RNASynthesis, REV1-REV7, Inhibitor, inhibit, JH RE 06, JH-RE-06, JHRE06, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Purity
99.24% (May vary between batches)
Solubility
DMSO:10.91 mg/mL (23.28 mM)
Smiles
CC (C) CC (=O) c1c (Nc2ccc (Cl) cc2Cl) [nH]c2c (Cl) ccc ([N+] ([O-]) =O) c2c1=O
Molecular Formula
C20H16Cl3N3O4
Molecular Weight
468.72
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one
CAS Number1361227-90-8
PubChem CID70691604
IUPAC Name8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one
Molecular FormulaC20H16Cl3N3O4
Molecular Weight468.7
XLogP6.7
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity739
SMILES
CC(C)CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)[N+](=O)[O-])Cl)NC3=C(C=C(C=C3)Cl)Cl
InChI
InChI=1S/C20H16Cl3N3O4/c1-9(2)7-15(27)17-19(28)16-14(26(29)30)6-4-11(22)18(16)25-20(17)24-13-5-3-10(21)8-12(13)23/h3-6,8-9H,7H2,1-2H3,(H2,24,25,28)
InChIKey
LRTXIQCBQIKIOH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one
CAS: 1361227-90-8
CID: 70691604
Formula: C20H16Cl3N3O4
MW: 468.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.7
XLogP36.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass467.020639
Monoisotopic Mass467.020639
Topological Polar Surface Area104 Ų
Heavy Atom Count30
Formal Charge0
Complexity739
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA3978-10JH-RE-06
A19168-1JH-RE-06 1mg
HY-126214S-01JH-RE-06-d6
A19168-100JH-RE-06 100mg
A19168-25JH-RE-06 25mg
A19168-50JH-RE-06 50mg
A19168-10JH-RE-06 10mg
A19168-5JH-RE-06 5mg
A19168-10mM-DJH-RE-06 10mM * 1mL in DMSO
MBS3607037JH-T4

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