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JH-II-127

CAT: 0013-GTR19167507-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167507-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JH-II-127 is a potent, orally bioavailable small molecule inhibitor of LRRK2, demonstrating nanomolar IC50 values against wild-type (6.6 nM), G2019S (2.2 nM), and A2016T (47.7 nM) variants. This compound is a valuable research tool for investigating LRRK2 biology and its implications in Parkinson's disease through in vitro and in vivo models.
CAS Number
1700693-08-8
Product Name Alternative
Ser935, 3T3 cells, parkinson's disease, LRRK2-A2016T, LRRK2-G2019S, LRRK2, Inhibitor, inhibit, JHII127, JH-II127, JH-II-127, JH-II 127, JH II 127, Leucine-rich repeat kinase 2, HEK293
Field of Research
Cell Biology
Purity
≥98% (May vary between batches)
Solubility
DMSO:30 mg/mL (71.97 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM)
Smiles
CNc1nc (Nc2ccc (cc2OC) C (=O) N2CCOCC2) nc2[nH]cc (Cl) c12
Molecular Formula
C19H21ClN6O3
Molecular Weight
416.86
Storage Conditions
-20°C
Notes
For research use only.

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BA3686-50JH-II-127
A15777-25JH-II-127 25mg
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A15777-10JH-II-127 10mg
A15777-5JH-II-127 5mg
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