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JNJ-10198409

CAT: 0013-GTR19174403-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174403-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-10198409 is a potent, ATP-competitive, and relatively selective inhibitor of platelet-derived growth factor receptor tyrosine kinases (PDGFRs), with IC50 values of 4.2 nM for PDGFR-β and 45 nM for PDGFR-α. This dual-mechanism agent exhibits antiangiogenic and direct antiproliferative activity, making it a useful research tool for studying PDGF signaling in cancer and fibrosis models both in vitro and in vivo.
CAS Number
627518-40-5
Product Name Alternative
Platelet-derived growth factor receptor, PDGFRα, PDGFRβ, Inhibitor, JNJ 10198409, JNJ-​10198409, JNJ10198409, JNJ-10198409, inhibit, PDGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
95.55% (May vary between batches)
Solubility
DMSO:83.33 mg/mL (256.13 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.14 mM)
Smiles
COc1cc2Cc3c (Nc4cccc (F) c4) n[nH]c3-c2cc1OC
Molecular Formula
C18H16FN3O2
Molecular Weight
325.34
Storage Conditions
-20°C
Notes
For research use only.

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6976/50JNJ 10198409
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A22554-100JNJ-10198409 100mg
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