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LSZ-102

CAT: 0013-GTR19174337-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174337-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSZ-102 is a potent and selective estrogen receptor degrader with an IC50 of 0.2 nM. It is a valuable research tool for investigating ERα-positive breast cancer in both cellular and animal models, facilitating studies on targeted protein degradation and therapeutic mechanisms.
CAS Number
2135600-76-7
Product Name Alternative
LSZ 102, LSZ102, LSZ-102, EstrogenReceptor, estrogen receptor, Estrogen Receptor, ERR
Field of Research
Metabolism Research
Purity
97.84% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.25 mM) ; DMSO:90 mg/mL (191.3 mM)
Smiles
CC (F) (F) c1cc (F) ccc1-c1sc2cc (O) ccc2c1Oc1ccc (\C=C\C (O) =O) cc1
Molecular Formula
C25H17F3O4S
Molecular Weight
470.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lsz-102

LSZ-102 is under investigation in clinical trial NCT02734615 (Phase I/Ib Trial of LSZ102 Single Agent or LSZ102 + LEE011 or LSZ102 + BYL719 in ER+ Breast Cancers).

CAS Number2135600-76-7
PubChem CID118574930
IUPAC Name(E)-3-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxy-1-benzothiophen-3-yl]oxy]phenyl]prop-2-enoic acid
Molecular FormulaC25H17F3O4S
Molecular Weight470.5
XLogP6.6
Topological Polar Surface Area95
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity712
SMILES
CC(C1=C(C=CC(=C1)F)C2=C(C3=C(S2)C=C(C=C3)O)OC4=CC=C(C=C4)/C=C/C(=O)O)(F)F
InChI
InChI=1S/C25H17F3O4S/c1-25(27,28)20-12-15(26)5-9-18(20)24-23(19-10-6-16(29)13-21(19)33-24)32-17-7-2-14(3-8-17)4-11-22(30)31/h2-13,29H,1H3,(H,30,31)/b11-4+
InChIKey
SJXNPGGVGZXKKI-NYYWCZLTSA-N
Chemical Structure
2D Structure
2D structure of Lsz-102
CAS: 2135600-76-7
CID: 118574930
Formula: C25H17F3O4S
MW: 470.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.5
XLogP36.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass470.07996468
Monoisotopic Mass470.07996468
Topological Polar Surface Area95 Ų
Heavy Atom Count33
Formal Charge0
Complexity712
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BUP01344-01LSZ-102
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A19728-100LSZ-102 100mg
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