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BGB-102

CAT: 0013-GTR19206440-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206440-01Size:1 mg
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Description
BGB-102
CAS Number
807640-87-5
Product Name Alternative
BGB 102, BGB102, BGB-102, EGFR, FLT3, HER4, HER2, JNJ 26483327, JNJ26483327, JNJ-26483327, Yes, VEGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.02% (May vary between batches)
Smiles
BrC1=CC=C2C (=C1) NC=3N=CN=C4C=C (OC) C (OCCCCCN (C) C2) =CC43
Molecular Formula
C22H25BrN4O2
Molecular Weight
457.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Jnj-26483327

Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).

CAS Number807640-87-5
PubChem CID11952856
IUPAC Name5-bromo-18-methoxy-10-methyl-16-oxa-2,10,21,23-tetrazatetracyclo[15.6.2.03,8.020,24]pentacosa-1(23),3(8),4,6,17,19,21,24-octaene
Molecular FormulaC22H25BrN4O2
Molecular Weight457.4
XLogP4.7
Topological Polar Surface Area59.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count29
Formal Charge0
Complexity513
SMILES
CN1CCCCCOC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C1)C=CC(=C4)Br)OC
InChI
InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26)
InChIKey
JXDYOSVKVSQGJM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jnj-26483327
CAS: 807640-87-5
CID: 11952856
Formula: C22H25BrN4O2
MW: 457.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight457.4
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass456.11609
Monoisotopic Mass456.11609
Topological Polar Surface Area59.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity513
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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