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Pyr6

CAT: 0013-GTR19174247-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174247-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyr6 is a selective TRPC3 channel inhibitor with an IC50 of 0.49 μM, demonstrating higher potency against CRAC-mediated calcium entry. This compound is a valuable research tool for studying receptor-operated calcium signaling in cellular models, including mast cell and immune cell research.
CAS Number
245747-08-4
Product Name Alternative
Inhibitor, N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide, Pyr 6, Pyr6, Pyr-6, inhibit, Transient receptor potential channels, TRP Channel, TRPC3, TRPChannel, TRPVChannel, TRPV Channel
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
98.89% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (23.91 mM) ; DMSO:95 mg/mL (227.13 mM)
Smiles
Fc1cnccc1C (=O) Nc1ccc (cc1) -n1nc (cc1C (F) (F) F) C (F) (F) F
Molecular Formula
C17H9F7N4O
Molecular Weight
418.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide
CAS Number245747-08-4
PubChem CID10598093
IUPAC NameN-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamide
Molecular FormulaC17H9F7N4O
Molecular Weight418.27
XLogP3.6
Topological Polar Surface Area59.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity577
SMILES
C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
InChIKey
XZIQSOZOLJJMFN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide
CAS: 245747-08-4
CID: 10598093
Formula: C17H9F7N4O
MW: 418.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.27
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass418.06645806
Monoisotopic Mass418.06645806
Topological Polar Surface Area59.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity577
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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