Pyr6

CAT: 0931-T16688-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T16688-01Size:5 mg
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CAS Number
245747-08-4
Target
Calcium Channel|||TRP/TRPV Channel
Related Pathways
Metabolism|||Membrane transporter/Ion channel
Purity
0.9918
Bioactivity
Pyr6 (N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells) .Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.
Smiles
Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
Molecular Formula
C17H9F7N4O
Molecular Weight
418.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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