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R-268712

CAT: 0013-GTR19174237-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174237-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R-268712 is a potent and orally bioavailable inhibitor of the TGF-β type I receptor/ALK5, exhibiting an IC50 of 2.5 nM. This small molecule is a valuable research tool for investigating TGF-β signaling in fibrosis, oncology, and immunology research, applicable in both cellular and animal models.
CAS Number
879487-87-3
Product Name Alternative
Renal fibrosis, TGFb, TGF-b/Smad, TGFβ, TGF-β, TGF-β/Smad, TGF-β Receptor, TGFbeta, TGF-beta, TGF-beta/Smad, TGFbeta/Smad, Smad, R 268712, Thy1 nephritis, R268712, R-268712, Transforming growth factor beta, Transforming growth factor beta receptors, UUO, inhibit, Inhibitor, HFL-1, glomerulonephritis, glomerulosclerosis, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), ALK5, ALK tyrosine kinase receptor, CKD, Cluster of differentiation 246, CD246
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.61% (May vary between batches)
Solubility
DMSO:250 mg/mL (687.97 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.01 mM)
Smiles
Cc1cccc (n1) -c1n[nH]cc1-c1ccc (F) c (c1) -c1cnn (CCO) c1
Molecular Formula
C20H18FN5O
Molecular Weight
363.39
Storage Conditions
-20°C
Notes
For research use only.

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BA8783-25R-268712
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A16207-5R-268712 5mg
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