Chromogranin A/CHGA (Neuroendocrine Marker)

• Gene Name:

  [CHGA]

• NCBI Gene ID:

  1113

• Reactivity:

  Human.
  Does not react with rat. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

• Other Gene Names:

  [CHGA; CHGA; CGA; CgA; SP-I]

• Short Name:

  [Chromogranin A/CHGA]

• Other Product Names:

  [chromogranin-A isoform 1 preproprotein; Chromogranin-A; chromogranin-A; chromogranin A; SL21]

• NCBI GI Number:

  4502805

• NCBI Accession Number:

  NP_001266.1

• NCBI GB Accession Number:

  NM_001275.3

• Uniprot Accession Number:

  P10645