ER-beta1 (Estrogen Receptor beta-1) Mouse Monoclonal Antibody

ER-beta1 (Estrogen Receptor beta-1) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [ESR2]
• NCBI Gene ID: 2100
• Reactivity: Human
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
• Other Gene Names: [ESR2; ESR2; Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA; ESTRB; NR3A2; ER-beta]
• Short Name: [ER-beta1 (Estrogen Receptor beta-1)]
• Other Product Names: [estrogen receptor beta isoform 2; Estrogen receptor beta; estrogen receptor beta; estrogen receptor 2; Nuclear receptor subfamily 3 group A member 2]
• NCBI GI Number: 94538325
• NCBI Accession Number: NP_001035365.1
• NCBI GB Accession Number: NM_001040275.1
• Uniprot Accession Number: Q92731