Anti-ER-beta1 (Estrogen Receptor beta-1) ESR2 Monoclonal Antibody

Anti-ER-beta1 (Estrogen Receptor beta-1) ESR2 Monoclonal Antibody

• Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
• Description: Boster Bio Anti-ER-beta1 (Estrogen Receptor beta-1) ESR2 Monoclonal Antibody (Catalog # M00786). Tested in Flow Cytometry, IF, WB, IHC applications. This antibody reacts with Human, Monkey, Mouse, Rat, Pig, Horse, Sheep.
• Synonyms: Estrogen receptor beta;ER-beta;Nuclear receptor subfamily 3 group A member 2;ESR2;ESTRB, NR3A2;
• CAS Number: 9007-83-4
• Gene Name: ESR2
• UniProt: Q92731
• Host: Mouse
• Reactivity: Human, Monkey, Mouse, Rat, Pig, Horse, Sheep
• Immunogen: C-terminus fragment of recombinant human estrogen receptor beta protein
• Clonality: Monoclonal
• Applications: Flow Cytometry, IF, WB, IHC
• Purification: 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
• Concentration: Purified antibody with BSA and azide at 200ug/ml
• Form: Liquid
• Molecular Weight: 59216 MW
• Components: Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage Conditions: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Fragment: IgG2a, kappa
• Clone ID: Clone: Clone: ERb455