SOX10 (Melanoma Marker) Mouse Monoclonal Antibody

• Gene Name:

  [SOX10]

• NCBI Gene ID:

  6663

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

• Other Gene Names:

  [SOX10; SOX10; DOM; WS4; PCWH; WS2E; WS4C]

• Short Name:

  [SOX10]

• Other Product Names:

  [transcription factor SOX-10; Transcription factor SOX-10; transcription factor SOX-10; SRY-box 10]

• NCBI GI Number:

  5902104

• NCBI Accession Number:

  NP_008872.1

• NCBI GB Accession Number:

  NM_006941.3

• Uniprot Accession Number:

  P56693

• CAS Number:

  9007-83-4