Tyrosinase (Melanoma Marker)

• Gene Name:

  [TYR]

• NCBI Gene ID:

  7299

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3, 4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

• Other Gene Names:

  [TYR; TYR; ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3]

• Short Name:

  [Tyrosinase]

• Other Product Names:

  [tyrosinase; Tyrosinase; tyrosinase; tyrosinase; LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB]

• NCBI GI Number:

  4507753

• NCBI Accession Number:

  NP_000363.1

• NCBI GB Accession Number:

  NM_000372.4

• Uniprot Accession Number:

  P14679