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Amuvatinib

CAT: 0013-GTR19173794-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173794-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amuvatinib (MP470) is an orally available small molecule investigational agent with potential antitumor properties. It has been studied in vitro and in vivo for its activity against various cancer cell lines, particularly in research focusing on receptor tyrosine kinase inhibition and DNA repair pathways.
CAS Number
850879-09-3
Product Name Alternative
DNA Synthesis, DNASynthesis, cRET, CD117, Cluster of differentiation antigen 135, CD135, c-Kit, cKit, c-Kit (D816H), cMet, cMet/HGFR, c-Met, c-Met/HGFR, Apoptosis, Amuvatinib, inhibit, MP 470, MP470, MP-470, Platelet-derived growth factor receptor, PDGFR, Fms like tyrosine kinase 3, FLT3, FLT3 (D835Y), Inhibitor, HGFR, HPK56, HPK-56, HPK 56, RAD51, PDGFRα (V561D), RNA Synthesis, RNASynthesis, RET, SCFR
Field of Research
Cardiovascular Research, Cell Biology, Molecular Biology, Signal Transduction
Purity
98.48% (May vary between batches)
Solubility
DMSO:50 mg/mL (111.73 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.47 mM)
Smiles
C (NCC=1C=C2C (=CC1) OCO2) (=S) N3CCN (C4=C5C (C=6C (O5) =CC=CC6) =NC=N4) CC3
Molecular Formula
C23H21N5O3S
Molecular Weight
447.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Amuvatinib

N-(1,3-benzodioxol-5-ylmethyl)-4-(4-benzofuro[3,2-d]pyrimidinyl)-1-piperazinecarbothioamide is a N-arylpiperazine.

CAS Number850879-09-3
PubChem CID11282283
IUPAC NameN-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide
Molecular FormulaC23H21N5O3S
Molecular Weight447.5
XLogP3.5
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count32
Formal Charge0
Complexity678
SMILES
C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6
InChI
InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)
InChIKey
FOFDIMHVKGYHRU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amuvatinib
CAS: 850879-09-3
CID: 11282283
Formula: C23H21N5O3S
MW: 447.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight447.5
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass447.13651072
Monoisotopic Mass447.13651072
Topological Polar Surface Area108 Ų
Heavy Atom Count32
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
9458-25Amuvatinib
MBS3845933-01Amuvatinib hydrochloride
HY-10206R-01Amuvatinib (Standard)
MBS577043Amuvatinib(MP470)
C07650-5mgAmuvatinib (MP-470)

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