Cyclin A

• Gene Name:

  [CCNA2]

• NCBI Gene ID:

  890

• Reactivity:

  Human, Mouse, Cow, African Green Monkey, Mink (Mustela).

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.

• Other Gene Names:

  [CCNA2; CCNA2; CCN1; CCNA; CCN1; CCNA; Cyclin-A]

• Short Name:

  [Cyclin A]

• Other Product Names:

  [cyclin-A2; Cyclin-A2; cyclin-A2; cyclin A2]

• NCBI GI Number:

  4502613

• NCBI Accession Number:

  NP_001228.1

• NCBI GB Accession Number:

  NM_001237.3

• Uniprot Accession Number:

  P20248