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BIX02189

CAT: 0013-GTR19173611-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173611-01Size:2 mg
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Description
BIX02189 is a potent, selective small-molecule inhibitor of the MEK5-ERK5 signaling pathway, exhibiting IC50 values of 1.5 nM for MEK5 and 59 nM for ERK5. This compound is a valuable research tool for investigating the role of this pathway in cancer, inflammation, and cardiovascular diseases in both cellular and animal models.
CAS Number
1265916-41-3
Product Name Alternative
BIX02189, BIX-02189, BIX 02189, ERK, Extracellular signal regulated kinases, Inhibitor, MEK, MAP2K, MAPKK, Mitogen-activated protein kinase kinase, inhibit
Field of Research
Signal Transduction
Purity
97.84% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM) ; DMSO:49.4 mg/mL (112.14 mM)
Smiles
CN (C) Cc1cccc (N\C (=C2/C (=O) Nc3cc (ccc23) C (=O) N (C) C) c2ccccc2) c1
Molecular Formula
C27H28N4O2
Molecular Weight
440.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

CAS Number1265916-41-3
PubChem CID135659062
IUPAC Name3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-N,N-dimethyl-1H-indole-6-carboxamide
Molecular FormulaC27H28N4O2
Molecular Weight440.5
XLogP4.5
Topological Polar Surface Area71.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity688
SMILES
CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O
InChI
InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,29,32H,17H2,1-4H3
InChIKey
ZGXOBLVQIVXKEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
CAS: 1265916-41-3
CID: 135659062
Formula: C27H28N4O2
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass440.22122615
Monoisotopic Mass440.22122615
Topological Polar Surface Area71.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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