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TWS119

CAT: 0013-GTR19173724-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19173724-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TWS119 is a selective inhibitor of glycogen synthase kinase-3 beta (GSK-3β) . Its application in research includes promoting neuronal differentiation in vitro and has been investigated in studies of neurogenesis and neuronal development.
CAS Number
601514-19-6
Product Name Alternative
Autophagy, inhibit, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK-3, GSK3, GSK-3β, Inhibitor, TWS119, TWS-119, TWS 119
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.02% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.28 mM) ; DMSO:60 mg/mL (188.48 mM)
Smiles
Nc1cccc (c1) -c1cc2c (Oc3cccc (O) c3) ncnc2[nH]1
Molecular Formula
C18H14N4O2
Molecular Weight
318.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tws119

3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.

CAS Number601514-19-6
PubChem CID9549289
IUPAC Name3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Molecular FormulaC18H14N4O2
Molecular Weight318.3
XLogP3.2
Topological Polar Surface Area97.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity424
SMILES
C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
InChI
InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tws119
CAS: 601514-19-6
CID: 9549289
Formula: C18H14N4O2
MW: 318.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight318.3
XLogP33.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass318.11167570
Monoisotopic Mass318.11167570
Topological Polar Surface Area97.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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