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Luminespib

CAT: 0013-GTR19173657-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173657-01Size:5 mg
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Description
Luminespib (VER-52296) is a potent and selective HSP90 inhibitor targeting both HSP90α and HSP90β isoforms. It demonstrates significant antitumor activity in preclinical studies, including in vitro cell-based assays and in vivo models for head and neck squamous cell carcinoma and other malignancies.
CAS Number
747412-49-3
Product Name Alternative
NVP-AUY922; VER-52296
Field of Research
Cardiovascular Research, Cell Biology, Immunology & Inflammation
Purity
>99%
Bioactivity
HSP90 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
CCNC (=O) c1noc (c1-c1ccc (CN2CCOCC2) cc1) -c1cc (C (C) C) c (O) cc1O
Molecular Formula
C26H31N3O5
Molecular Weight
465.5
References & Citations
Mohammed Fulayyih Aloufi et al. Luminespib protects against dexamethasone-induced hepatic, vascular, and metabolic abnormalities in rats Naunyn Schmiedebergs Arch Pharmacol, (2025)
Pubmed id
41273382
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
5- (2,4-Dihydroxy-5-propan-2-ylphenyl) -N-ethyl-4-[4- (morpholin-4-ylmethyl) phenyl]-1,2-oxazole-3-carboxamide

Chemical Information

Luminespib

Luminespib is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine. It has a role as an antineoplastic agent, an angiogenesis inhibitor and a Hsp90 inhibitor. It is a monocarboxylic acid amide, a member of resorcinols, a member of morpholines, a member of isoxazoles and an aromatic amide.

CAS Number747412-49-3
PubChem CID135539077
IUPAC Name5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Molecular FormulaC26H31N3O5
Molecular Weight465.5
XLogP3.5
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity650
SMILES
CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
InChI
InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChIKey
NDAZATDQFDPQBD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Luminespib
CAS: 747412-49-3
CID: 135539077
Formula: C26H31N3O5
MW: 465.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight465.5
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass465.22637110
Monoisotopic Mass465.22637110
Topological Polar Surface Area108 Ų
Heavy Atom Count34
Formal Charge0
Complexity650
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FL137696-01Luminespib
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T68760-01Luminespib mesylate
HY-10976Luminespib analog
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C07489-25mgLuminespib (NVP-AUY922)
200371Luminespib (AUY-922 )
MBS386359-01AUY922 (Luminespib, NVP-AUY922)
A10659-50AUY922 (Luminespib, NVP-AUY922) 50mg
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