Fedratinib

CAT: 0013-GTR19173525-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0013-GTR19173525-02Size:1 ml x 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Fedratinib is a potent, selective, and orally bioavailable ATP-competitive inhibitor of JAK2 and JAK2V617F. It induces apoptosis in tumor cells and is used in research for myeloproliferative neoplasms, with studies demonstrating efficacy in both cellular assays and animal models.

CAS Number

936091-26-8

Product Name Alternative

CRET, anti-cancer, anti-proliferation, Apoptosis, orally, JAK2, JAK, JAK2 (V617F), JAK2V617F, Janus kinase, myeloproliferative, Inhibitor, inhibit, FLT3, Fedratinib, phosphorylation, STAT5, SAR 302503, SAR302503, SAR-302503, RET, TG101348, TG-101348, TG 101348

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Purity

97.31% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:240 mg/mL (457.42 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:9.3 mg/mL (17.73 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

Cc1cnc (Nc2ccc (OCCN3CCCC3) cc2) nc1Nc1cccc (c1) S (=O) (=O) NC (C) (C) C

Molecular Formula

C27H36N6O3S

Molecular Weight

524.68

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Fedratinib

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide is a sulfonamide.

CAS Number	936091-26-8
PubChem CID	16722836
IUPAC Name	N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
Molecular Formula	C27H36N6O3S
Molecular Weight	524.7
XLogP	4.8
Topological Polar Surface Area	117
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Heavy Atom Count	37
Formal Charge	0
Complexity	787

SMILES

CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

InChI

InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChIKey

JOOXLOJCABQBSG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 936091-26-8

CID: 16722836

Formula: C27H36N6O3S

MW: 524.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	524.7
XLogP3	4.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	524.25696021
Monoisotopic Mass	524.25696021
Topological Polar Surface Area	117 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	787
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
FD151499-01	Fedratinib
CS-O-44789	Fedratinib-d8
C08814-5mg	Fedratinib (TG101348)
CS-O-44790	Fedratinib-d4
HY-10409R-01	Fedratinib (Standard)
HY-10409S	Fedratinib-d9
A9916-100	Fedratinib hydrochloride hydrate
AR-F09859-01	Fedratinib Impurity 3
AR-F09858-01	Fedratinib Impurity 2

Fedratinib

Chemical Information

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