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GSK-5959

CAT: 0013-GTR19173225-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173225-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK-5959 is a potent, selective, and cell-permeable small molecule inhibitor of the BRPF1 bromodomain, exhibiting an IC50 of approximately 80 nM. It demonstrates over 100-fold selectivity against 35 other bromodomains, including BRPF2/3 and BET family members. This inhibitor is a valuable chemical probe for investigating BRPF1 function in epigenetic regulation and related disease models in both cellular and in vivo contexts.
CAS Number
901245-65-6
Product Name Alternative
GSK 5959, GSK5959, GSK-5959, epigenetics, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit, Inhibitor, bromodomain, BRPF2, BRPF3, BRPF1, BRD1
Field of Research
Epigenetics & Chromatin
Purity
98.35% (May vary between batches)
Solubility
DMSO:10 mg/mL (25.35 mM)
Smiles
COc1ccccc1C (=O) Nc1cc2n (C) c (=O) n (C) c2cc1N1CCCCC1
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
CAS Number901245-65-6
PubChem CID15990224
IUPAC NameN-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
Molecular FormulaC22H26N4O3
Molecular Weight394.5
XLogP2.7
Topological Polar Surface Area65.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity609
SMILES
CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCCC4)N(C1=O)C
InChI
InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)
InChIKey
LTUGYAOMCKNTGG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
CAS: 901245-65-6
CID: 15990224
Formula: C22H26N4O3
MW: 394.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.5
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass394.20049070
Monoisotopic Mass394.20049070
Topological Polar Surface Area65.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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