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Sonidegib

CAT: 0013-GTR19173073-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173073-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sonidegib (Erismodegib) is a potent and selective Smoothened (Smo) antagonist that blocks Hedgehog (Hh) signaling, exhibiting IC50 values of 1.3 nM in mouse and 2.5 nM in human assays. This inhibitor is widely used in cancer research, particularly for studying basal cell carcinoma, in both in vitro and in vivo experimental models.
CAS Number
956697-53-3
Product Name Alternative
Sonidegib, Smoothened, Smo, Erismodegib, Inhibitor, Hedgehog, LDE 225, LDE225, LDE-225, NVP-LDE 225, NVP-LDE225, NVP-LDE-225, inhibit
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.3 mM) ; Ethanol:90 mg/mL (185.38 mM) ; DMSO:255 mg/mL (525.23 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CC1=C (C=CC=C1C (NC=2C=CC (=NC2) N3C[C@@H] (C) O[C@@H] (C) C3) =O) C4=CC=C (OC (F) (F) F) C=C4
Molecular Formula
C26H26F3N3O3
Molecular Weight
485.5
Storage Conditions
-20°C
Notes
For research use only.

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