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SP-141

CAT: 0013-GTR19173004-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173004-07Size:100 mg
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Description
SP-141 is a small molecule MDM2 inhibitor that induces the target's auto-ubiquitination and proteasomal degradation. It demonstrates anticancer activity in vitro and has shown efficacy in reducing tumor growth in vivo in breast cancer and pancreatic cancer xenograft models.
CAS Number
1253491-42-7
Product Name Alternative
Breast, degradation, auto-ubiquitination, cancer, pancreatic, inhibit, MDM-2/p53, Mdm2, Inhibitor, SP 141, SP141, SP-141
Field of Research
Cell Biology
Purity
98.01% (May vary between batches)
Solubility
DMSO:4.4 mg/mL (13.56 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.08 mM)
Smiles
COc1ccc2[nH]c3c (nccc3c2c1) -c1cccc2ccccc12
Molecular Formula
C22H16N2O
Molecular Weight
324.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-methoxy-1-(naphthalen-1-yl)-9H-pyrido(3,4-b)indole

an MDM2 inhibitor with antineoplastic activity; structure in first source

CAS Number1253491-42-7
PubChem CID59620153
IUPAC Name6-methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
Molecular FormulaC22H16N2O
Molecular Weight324.4
XLogP5.2
Topological Polar Surface Area37.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity469
SMILES
COC1=CC2=C(C=C1)NC3=C2C=CN=C3C4=CC=CC5=CC=CC=C54
InChI
InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChIKey
AABFWJDLCCDJJN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-methoxy-1-(naphthalen-1-yl)-9H-pyrido(3,4-b)indole
CAS: 1253491-42-7
CID: 59620153
Formula: C22H16N2O
MW: 324.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight324.4
XLogP35.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass324.126263138
Monoisotopic Mass324.126263138
Topological Polar Surface Area37.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity469
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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