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Wnt-C59

CAT: 0013-GTR19172729-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172729-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wnt-C59 (C59) is a potent and selective PORCN inhibitor that antagonizes Wnt signaling. It is widely used in both in vitro and in vivo research to investigate Wnt pathway roles in development, cancer, and stem cell biology.
CAS Number
1243243-89-1
Product Name Alternative
Bcatenin, C59, C-59, C 59, beta-catenin, betacatenin, Wnt, Wnt C59, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, Wnt-C59, Wnt-C-59, WntC59, Porcn, βcatenin
Field of Research
Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Porcupine inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/ml) .
Smiles
Cc1cc (ccn1) -c1ccc (CC (=O) Nc2ccc (cc2) -c2cccnc2) cc1
Molecular Formula
C25H21N3O
Molecular Weight
379.5
References & Citations
Ana Pozo-Agundo et al. Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes Eur J Pharmacol ., (2025)
Pubmed id
41423083
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4- (2-Methyl-4-pyridinyl) -N-[4- (3-pyridinyl) phenyl]benzeneacetamide

Chemical Information

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

a PORCN acyltransferase inhibitor; structure in first source

CAS Number1243243-89-1
PubChem CID57519544
IUPAC Name2-[4-(2-methyl-4-pyridinyl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
Molecular FormulaC25H21N3O
Molecular Weight379.5
XLogP4.2
Topological Polar Surface Area54.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity508
SMILES
CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4
InChI
InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChIKey
KHZOJCQBHJUJFY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
CAS: 1243243-89-1
CID: 57519544
Formula: C25H21N3O
MW: 379.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.5
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass379.168462302
Monoisotopic Mass379.168462302
Topological Polar Surface Area54.9 Ų
Heavy Atom Count29
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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