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TLR3-IN-1

CAT: 0013-GTR19172632-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172632-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor with an IC50 of 3.44 μM. It blocks dsRNA-induced TLR3 signaling and reduces pro-inflammatory cytokine production, such as TNF-α and IL-1β, in cellular models like RAW 264.7 macrophages, supporting its use in studying innate immunity and inflammatory diseases.
CAS Number
1279713-77-7
Product Name Alternative
CU-CPT 4a, CU CPT 4a, Inhibitor, inhibit, IL-1β, TLR3 IN 1, TLR3/dsRNA complex, TLR3IN1, TLR-3-IN-1, TLR3-IN-1, TLR3, Toll-like Receptor (TLR), TNF-α, protein-RNA interaction
Field of Research
Cell Biology, Immunology & Inflammation
Purity
97.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.62 mM) ; DMSO:250 mg/mL (661.69 mM)
Smiles
OC (=O) [C@@H] (Cc1ccccc1) NC (=O) c1sc2cc (F) ccc2c1Cl
Molecular Formula
C18H13ClFNO3S
Molecular Weight
377.82
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CU CPT 4a
CAS Number1279713-77-7
PubChem CID53242268
IUPAC Name(2R)-2-[(3-chloro-6-fluoro-1-benzothiophene-2-carbonyl)amino]-3-phenylpropanoic acid
Molecular FormulaC18H13ClFNO3S
Molecular Weight377.8
XLogP4.9
Topological Polar Surface Area94.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity503
SMILES
C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)C2=C(C3=C(S2)C=C(C=C3)F)Cl
InChI
InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1
InChIKey
IAASQMCXDRISAV-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of CU CPT 4a
CAS: 1279713-77-7
CID: 53242268
Formula: C18H13ClFNO3S
MW: 377.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight377.8
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass377.0288703
Monoisotopic Mass377.0288703
Topological Polar Surface Area94.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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