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MMAF

CAT: 0013-GTR19172572-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172572-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MonoMethyl auristatin F (MMAF) is a potent antimitotic agent that disrupts microtubule dynamics by inhibiting tubulin polymerization, thereby arresting cell division. This mechanism makes it a valuable payload in antibody-drug conjugates (ADCs) for cancer research, with applications in both in vitro cytotoxicity assays and in vivo xenograft studies.
CAS Number
745017-94-1
Product Name Alternative
ADC Payload, ADCCytotoxin, ADC Cytotoxin, Cytotoxicity (Karpas 299 cell), Inhibitor, MonoMethyl auristatin F, Monomethylauristatin F, MMAF, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, inhibit
Field of Research
Signal Transduction
Purity
97.00% (May vary between batches)
Solubility
DMSO:250 mg/mL (341.55 mM)
Smiles
CC[C@H] (C) C ([C@@H] (CC (=O) N1CCC[C@H]1[C@H] (OC) [C@@H] (C) C (=O) N[C@@H] (Cc1ccccc1) C (O) =O) OC) N (C) C (=O) [C@@H] (NC (=O) [C@@H] (NC) C (C) C) C (C) C
Molecular Formula
C39H65N5O8
Molecular Weight
731.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Monomethyl auristatin F

structure in first source

CAS Number745017-94-1
PubChem CID10395173
IUPAC Name(2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid
Molecular FormulaC39H65N5O8
Molecular Weight732.0
XLogP2.1
Topological Polar Surface Area167
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count21
Heavy Atom Count52
Formal Charge0
Complexity1160
SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
InChI
InChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15,17-18,23-26,28-30,32-35,40H,12,16,19-22H2,1-11H3,(H,41,46)(H,42,47)(H,49,50)/t25-,26+,28-,29-,30+,32-,33-,34-,35+/m0/s1
InChIKey
MFRNYXJJRJQHNW-DEMKXPNLSA-N
Chemical Structure
2D Structure
2D structure of Monomethyl auristatin F
CAS: 745017-94-1
CID: 10395173
Formula: C39H65N5O8
MW: 732.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight732.0
XLogP32.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count21
Exact Mass731.48331405
Monoisotopic Mass731.48331405
Topological Polar Surface Area167 Ų
Heavy Atom Count52
Formal Charge0
Complexity1160
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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