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Xanthohumol

CAT: 0013-GTR19173013-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173013-01Size:5 mg
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Description
Xanthohumol is a prenylated chalcone with chemopreventive properties, acting as a COX-1 and COX-2 inhibitor. It is widely used in research areas such as cancer chemoprevention, inflammation, and metabolic studies, with applications in both in vitro and in vivo experimental models.
CAS Number
6754-58-1
Product Name Alternative
Xanthohumol, Influenza Virus, InfluenzaVirus, mono- acylglycerol acyltransferase, inhibit, HSV, Inhibitor, Herpes simplex virus, acyl-CoA:cholesterol acyltransferase, Acyltransferase, Apoptosis, Diacylglycerol acyltransferase, Diglyceride acyltransferase, Cyclooxygenase, Cytomegalovirus, COX, CMV
Field of Research
Cell Biology
Purity
>98%
Bioactivity
VCP inhibitor / Autophagy inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml) .
Smiles
COc1cc (O) c (C\C=C (/C) C) c (O) c1C (=O) \C=C\c1ccc (O) cc1
Molecular Formula
C21H22O5
Molecular Weight
354.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Xanthohumol

Xanthohumol is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells. It has a role as an antiviral agent, a metabolite, an antineoplastic agent, an EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor, an anti-HIV-1 agent and an apoptosis inducer. It is a member of chalcones, a polyphenol and an aromatic ether. It is a conjugate acid of a xanthohumol(1-).

CAS Number6754-58-1
PubChem CID639665
IUPAC Name(E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Molecular FormulaC21H22O5
Molecular Weight354.4
XLogP5.1
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity514
SMILES
CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O)C
InChI
InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChIKey
ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Chemical Structure
2D Structure
2D structure of Xanthohumol
CAS: 6754-58-1
CID: 639665
Formula: C21H22O5
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP35.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass354.14672380
Monoisotopic Mass354.14672380
Topological Polar Surface Area87 Ų
Heavy Atom Count26
Formal Charge0
Complexity514
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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