TH287

CAT: 0013-GTR19172443-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19172443-01Size:1 mg

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Description

TH287 is a selective small molecule inhibitor primarily targeting the nucleotide sanitizing enzyme MTH1 (NUDT1) . It exhibits lower potency against related NUDT family members. This inhibitor is a valuable research tool for studying oxidative DNA damage repair mechanisms in cancer cell lines and in vivo tumor models.

CAS Number

1609960-30-6

Product Name Alternative

DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, MTH1, RNA Synthesis, RNASynthesis, TH287, TH-287, TH-287 Hydrochloride, TH 287, TH 287 Hydrochloride

Field of Research

Cell Biology, Molecular Biology

Purity

96.95% (May vary between batches)

Solubility

DMSO:49 mg/mL (182.07 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.43 mM) ; Ethanol:10 mg/mL (37.16 mM)

Smiles

CNc1cc (nc (N) n1) -c1cccc (Cl) c1Cl

Molecular Formula

C11H10Cl2N4

Molecular Weight

269.13

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

CAS Number	1609960-30-6
PubChem CID	73441664
IUPAC Name	6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
Molecular Formula	C11H10Cl2N4
Molecular Weight	269.13
XLogP	3.1
Topological Polar Surface Area	63.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	17
Formal Charge	0
Complexity	254

SMILES

CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N

InChI

InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17)

InChIKey

URWCXPXBBITYLR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1609960-30-6

CID: 73441664

Formula: C11H10Cl2N4

MW: 269.13

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	269.13
XLogP3	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	268.0282517
Monoisotopic Mass	268.0282517
Topological Polar Surface Area	63.8 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	254
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19208078-01	TH257

Alternative Products

Catalog	Name
406660	TH287
T2069L-01	TH287 hydrochloride
MBS131208-01	TH287 HCl
HY-16965A	TH287 (hydrochloride)
A15536-100	TH287 100mg
A15536-50	TH287 50mg
A15536-10	TH287 10mg
A15536-2	TH287 2mg
A15536-1	TH287 1mg
A15536-25	TH287 25mg

TH287

Chemical Information

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