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TH287 hydrochloride

CAT: 0931-T2069L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2069L-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1638211-05-8
Target
DNA/RNA Synthesis, MTH1
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
TH287 is a selective MTH1 inhibitor (IC50 : 0.8 nM) . It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Smiles
NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
Molecular Formula
C11H11Cl3N4
Molecular Weight
305.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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A15536-2TH287 2mg
A15536-1TH287 1mg
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