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TH287 hydrochloride

CAT: 0013-GTR19172440-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172440-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH287 is a potent and selective MTH1 inhibitor with an IC50 of 0.8 nM. It induces cytotoxicity in cancer cells by promoting the incorporation of oxidized dNTPs into DNA, causing DNA damage. This mechanism has demonstrated therapeutic efficacy in patient-derived xenograft (PDX) mouse models, supporting its use in oncology research.
CAS Number
1638211-05-8
Product Name Alternative
DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, inhibit, MTH1, Inhibitor, TH 287, TH 287 Hydrochloride, TH287, TH-287, TH287 Hydrochloride, TH287 hydrochloride, TH-287 Hydrochloride, TH-287 hydrochloride, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Purity
99.50% (May vary between batches)
Solubility
DMSO:27.5 mg/mL (89.99 mM)
Smiles
NC1=NC (C2=CC=CC (Cl) =C2Cl) =CC (NC) =N1.[H]Cl
Molecular Formula
C11H11Cl3N4
Molecular Weight
305.59
Storage Conditions
-20°C
Notes
For research use only.

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