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Miransertib

CAT: 0013-GTR19172264-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172264-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Miransertib (ARQ-092) is a potent, selective, and orally available allosteric inhibitor of Akt. It is widely used in preclinical research to investigate oncogenic PI3K/Akt pathway signaling, demonstrating activity in both in vitro cellular assays and in vivo xenograft models for cancers and overgrowth syndromes.
CAS Number
1313881-70-7
Product Name Alternative
AKT inhibitor 2, Akt1, AKT1-E17K, Akt2, Akt3, Akt, anti-tumor, anti-proliferative, ARQ092, ARQ-092, ARQ 092, Inhibitor, inhibit, Miransertib, Parasite, p-Akt, p-PRAS40, Protein kinase B, PKB
Field of Research
Infectious Disease & Virology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.31 mM) ; DMSO:12.75 mg/mL (29.48 mM)
Smiles
Nc1ncccc1-c1nc2ccc (nc2n1-c1ccc (cc1) C1 (N) CCC1) -c1ccccc1
Molecular Formula
C27H24N6
Molecular Weight
432.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Miransertib

Miransertib is under investigation in clinical trial NCT01473095 (Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma).

CAS Number1313881-70-7
PubChem CID53262401
IUPAC Name3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Molecular FormulaC27H24N6
Molecular Weight432.5
XLogP3.8
Topological Polar Surface Area95.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity653
SMILES
C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
InChI
InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
InChIKey
HNFMVVHMKGFCMB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Miransertib
CAS: 1313881-70-7
CID: 53262401
Formula: C27H24N6
MW: 432.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight432.5
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass432.20624479
Monoisotopic Mass432.20624479
Topological Polar Surface Area95.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity653
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1931-5Miransertib
T22247-01Miransertib hydrochloride
207082Miransertib HCl
T70152-01Miransertib mesylate
HY-19719A-01Miransertib (hydrochloride)
A22376-25Miransertib hydrochloride 25mg
A22376-10Miransertib hydrochloride 10mg
C12232-5mgMiransertib (ARQ-092)
A22376-5Miransertib hydrochloride 5mg
A22376-1Miransertib hydrochloride 1mg

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