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AS-252424

CAT: 0013-GTR19172075-08Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172075-08Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS-252424 is a potent and selective small molecule inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ), exhibiting an IC50 of 33 nM and over 10-fold selectivity against PI3Kα. This compound is a valuable research tool for studying PI3Kγ signaling in immune cell function, inflammation, and cancer, with utility in both in vitro and in vivo experimental models.
CAS Number
900515-16-4
Product Name Alternative
PI3Kγ, PI3Kα, PI3K, Phosphoinositide 3-kinase, inhibit, Inhibitor, Casein Kinase, CaseinKinase, AS252424, AS-252424, AS 252424, CK2
Field of Research
Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.06% (May vary between batches)
Solubility
DMSO:47.5 mg/mL (155.59 mM)
Smiles
Oc1cc (F) ccc1-c1ccc (\C=C2/SC (=O) NC2=O) o1
Molecular Formula
C14H8FNO4S
Molecular Weight
305.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AS-252424
CAS Number900515-16-4
PubChem CID11630874
IUPAC Name(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
Molecular FormulaC14H8FNO4S
Molecular Weight305.28
XLogP2.7
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity484
SMILES
C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3
InChI
InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6-
InChIKey
OYYVWNDMOQPMGE-SDQBBNPISA-N
Chemical Structure
2D Structure
2D structure of AS-252424
CAS: 900515-16-4
CID: 11630874
Formula: C14H8FNO4S
MW: 305.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.28
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass305.01580707
Monoisotopic Mass305.01580707
Topological Polar Surface Area105 Ų
Heavy Atom Count21
Formal Charge0
Complexity484
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T6208-01AS-252424
FA101250-01AS 252424

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